Apparently the drug, Capacitabine he was gorging down was the culprit behind this knock off.
Let’s surmise you have planned for a vacation in the United States but you are not able to move out of the airport as you are held by the immigration officials for many hours since they were not able to track down your fingerprints. It might sound completely bizarre, albeit it is cent percent true. This is the case of 2009 published in many journals when a person from Singapore was held for four hours.
This 62 year-old person was a cancer patient who had gone to visit his relatives in the United States and was put on the medication of Capecitabine to eschew the deluge of cancer again and for the security reasons he was detained at the airport. Apparently the drug, Capecitabine, he was gorging down was the culprit behind this knock off.
The drug, called capecitabine, is commonly used to treat cancers in the head and neck, breast, stomach and colorectal. Capecitabine, is an US based FDA approved chemotherapy drug, an antimetabolite. As gnawed down the drug, in the body it is broken down into products that interfere with the synthesis of DNA, RNA, and proteins thus inhibiting the division of cancer cells.
This drug causes one side-effect, chronic inflammation in the palms or soles in the feet and the skin can peel, bleed and develop ulcers or blisters, hand-foot syndrome, popularly known as HFS. Hand-foot syndrome, a common cutaneous adverse effect associated with certain chemotherapy drugs. HFS is characterized by erythema, edema, and burning sensation, especially over palmoplantar surfaces. The pathogenesis of this syndrome is yet unknown albeit is believed to be a toxic reaction due to the local accumulation of the drug with consequent degeneration and necrosis of the sweat glands.
Studies revealed that capecitabine-induced HFS may be related to the overexpression of the COX-2 enzyme in the hands and feet, metabolism of capecitabine in small sweat glands, or mechanical compression and can be speculated that COX-2 inhibitors can treat or prevent capecitabine-induced HFS, as the dosage of celecoxib.
Reducing capecitabine doses and delaying chemotherapy can be a key way to relieve symptoms as most of the experts suggest . The therapeutic methods of HFS as well as the topical antiperspirants, urea ointment, antioxidants, or regional cooling might not be able to completely prevent or cure the effects of HFS, especially the loss of fingerprints. As the loss of fingerprints is a low-risk adverse reaction. However, as a type of unique personal information, fingerprints are widely used for personal identification for electronic devices. As the loss of fingerprints might bring inconvenience to these patients.
Comments